VEGF is crucial for metaphyseal bone vascularization. In contrast, the angiogenic factors required for vascularization of epiphyseal cartilage are unknown, although this represents a developmentally and clinically important aspect of bone growth. The
Christa Maes, Ingrid Stockmans, Karen Moermans, Riet Van Looveren, Nico Smets, Peter Carmeliet, Roger Bouillon, Geert Carmeliet
Quantitative RT-PCR analysis of effect of hypoxia on expression of VEGF (isoforms), VEGF receptors, and HIFs in cultured embryonic hind limbs and primary chondrocytes