Ushma Neill with the Journal of Clinical Investigation Series, Conversations with Giants in Medicine met Dr. Elias Zerhouni at the Lasker Awards in September of 2023 and jumped at the opportunity to be able to spend an hour with him. Zerhouni, who is Professor Emeritus at Johns Hopkins University and Vice Chairman and President of OPKO Health, is a radiologist by training, who focused much of his research on CT and MRI-based imaging methods to diagnose cancer and cardiovascular diseases. He notably served as the director of the US National Institutes of Health from 2002 to 2008 and later as president of global research and development at Sanofi.
In this episode, Jayme Locke and Maggie Jones-Carr explain the histologic outcomes of a series of brain-dead human recipients of a porcine kidney xenotransplant using exclusively FDA-approved medications, with and without anti-C5 monoclonal antibody.
In this episode, Shashwat Tripathi and Hinda Najem discuss how, using scRNA-seq, their analysis shows that CAFs, specifically the immune modulatory subtype, are increased in frequency as a function of glioma grade. Notably, collagen is a key ligand for the immune checkpoint LAIR-1. The study also characterizes which collagens are present in gliomas and their anatomical locations within the tumor microenvironment that can serve as a reference for the scientific community.
In this episode, Laszlo Farkas explains that the results of this study indicate that reduced endothelial expression of endolysosomal RAB7 causes dysregulation of autophagy, mitochondrial dysfunction and endothelial senescence, and induces spontaneous PH.
In this episode, Ushma Neill speaks with physician and geneticist Dr. Funmi Olopade. Dr. Olopade is the founding director of the Center for Clinical Cancer Genetics and Global Health at the University of Chicago. Olopade's research is focused on gaining a better understanding of the root causes and genomic basis of cancer in diverse populations. She is internationally renowned for her work in inherited cancer syndromes and for her clinical expertise in early detection and prevention of breast cancer in high-risk women.