[HTML][HTML] Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal …
Epithelial-mesenchymal transition plays an important role in many patho-physiological
processes, including cancer invasion and metastatic progression. Hepatocyte nuclear factor
6 (HNF6) has been known to be an important factor for both physiological and pathological
functions in liver and pancreas. However, its role in EMT and lung cancer progression
remains unidentified. We observed that HNF6 level can be down-regulated by TGF-β1 in
human lung cancer cells. Knockdown of HNF6 induced EMT and increased cell migration. In …
processes, including cancer invasion and metastatic progression. Hepatocyte nuclear factor
6 (HNF6) has been known to be an important factor for both physiological and pathological
functions in liver and pancreas. However, its role in EMT and lung cancer progression
remains unidentified. We observed that HNF6 level can be down-regulated by TGF-β1 in
human lung cancer cells. Knockdown of HNF6 induced EMT and increased cell migration. In …