[HTML][HTML] Loss of HNF6 expression correlates with human pancreatic cancer progression
KR Pekala, X Ma, PA Kropp, CP Petersen… - Laboratory …, 2014 - Elsevier
Normal pancreatic epithelium progresses through various stages of pancreatic
intraepithelial neoplasms (PanINs) in the development of pancreatic ductal adenocarcinoma
(PDAC). Transcriptional regulation of this progression is poorly understood. In mouse, the
hepatic nuclear factor 6 (Hnf6) transcription factor is expressed in ductal cells and at lower
levels in acinar cells of the adult pancreas, but not in mature endocrine cells. Hnf6 is critical
for terminal differentiation of the ductal epithelium during embryonic development and for …
intraepithelial neoplasms (PanINs) in the development of pancreatic ductal adenocarcinoma
(PDAC). Transcriptional regulation of this progression is poorly understood. In mouse, the
hepatic nuclear factor 6 (Hnf6) transcription factor is expressed in ductal cells and at lower
levels in acinar cells of the adult pancreas, but not in mature endocrine cells. Hnf6 is critical
for terminal differentiation of the ductal epithelium during embryonic development and for …