[HTML][HTML] Regulatory B cells: phenotype, function and role in transplantation
CM Wortel, S Heidt - Transplant immunology, 2017 - Elsevier
While B cells are traditionally known for their roles in antibody production, antigen
presentation and cytokine production, recent studies have highlighted the existence of B
cells with regulatory properties, which have been termed Bregs, analogous to regulatory T
cells (Tregs). Bregs have been found to play a role in autoimmune disease, malignancies,
infections, and may also be involved in solid organ transplantation. Their main mechanism
of action is by promoting the development of Tregs while suppressing effector CD4+ and …
presentation and cytokine production, recent studies have highlighted the existence of B
cells with regulatory properties, which have been termed Bregs, analogous to regulatory T
cells (Tregs). Bregs have been found to play a role in autoimmune disease, malignancies,
infections, and may also be involved in solid organ transplantation. Their main mechanism
of action is by promoting the development of Tregs while suppressing effector CD4+ and …