[HTML][HTML] Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing
S Munné, D Wells - Fertility and sterility, 2017 - Elsevier
A significant proportion of human preimplantation embryos produced during the course of in
vitro fertilization (IVF) treatments contain two or more cytogenetically distinct cell lines. This
phenomenon, known as chromosomal mosaicism, can involve the presence of cells with
different types of aneuploidy in the absence of any normal cells or a mixture of euploid and
abnormal cells. Although a high prevalence of mosaicism at the cleavage and blastocyst
stages has been appreciated for two decades, the precise frequency of the phenomenon …
vitro fertilization (IVF) treatments contain two or more cytogenetically distinct cell lines. This
phenomenon, known as chromosomal mosaicism, can involve the presence of cells with
different types of aneuploidy in the absence of any normal cells or a mixture of euploid and
abnormal cells. Although a high prevalence of mosaicism at the cleavage and blastocyst
stages has been appreciated for two decades, the precise frequency of the phenomenon …