The biogenesis and precise control of RNA m6A methylation
N 6-Methyladenosine (m 6 A) is the most prevalent internal RNA modification in mRNA, and
has been found to be highly conserved and hard-coded in mammals and other eukaryotic
species. The importance of m 6 A for gene expression regulation and cell fate decisions has
been well acknowledged in the past few years. However, it was only until recently that the
mechanisms underlying the biogenesis and specificity of m 6 A modification in cells were
uncovered. We review up-to-date knowledge on the biogenesis of the RNA m 6 A …
has been found to be highly conserved and hard-coded in mammals and other eukaryotic
species. The importance of m 6 A for gene expression regulation and cell fate decisions has
been well acknowledged in the past few years. However, it was only until recently that the
mechanisms underlying the biogenesis and specificity of m 6 A modification in cells were
uncovered. We review up-to-date knowledge on the biogenesis of the RNA m 6 A …
N6-Methyladenosine (m6A) is the most prevalent internal RNA modification in mRNA, and has been found to be highly conserved and hard-coded in mammals and other eukaryotic species. The importance of m6A for gene expression regulation and cell fate decisions has been well acknowledged in the past few years. However, it was only until recently that the mechanisms underlying the biogenesis and specificity of m6A modification in cells were uncovered. We review up-to-date knowledge on the biogenesis of the RNA m6A modification, including the cis-regulatory elements and trans-acting factors that determine general de novo m6A deposition and modulate cell type-specific m6A patterns, and we discuss the biological significance of such regulation.
cell.com