[HTML][HTML] Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization
W Hao, CPB Chang, CC Tsao, J Xu - Journal of biological chemistry, 2010 - ASBMB
Cancer cells constantly adapt to oxidative phosphorylation (OXPHOS) suppression resulting
from hypoxia or mitochondria defects. Under the OXPHOS suppression, AMP-activated
protein kinase (AMPK) regulates global metabolism adjustments, but its activation has been
found to be transient. Whether cells can maintain cellular ATP homeostasis and survive
beyond the transient AMPK activation is not known. Here, we study the bioenergetic
adaptation to the OXPHOS inhibitor oligomycin in a group of cancer cells. We found that …
from hypoxia or mitochondria defects. Under the OXPHOS suppression, AMP-activated
protein kinase (AMPK) regulates global metabolism adjustments, but its activation has been
found to be transient. Whether cells can maintain cellular ATP homeostasis and survive
beyond the transient AMPK activation is not known. Here, we study the bioenergetic
adaptation to the OXPHOS inhibitor oligomycin in a group of cancer cells. We found that …