We utilized mouse models to elucidate the immunologic mechanisms of functional graft loss
during mixed antibody-mediated rejection of renal allografts (mixed AMR), in which humoral
and cellular responses to the graft occur concomitantly. Although the majority of T cells in the
graft at the time of rejection were CD8 T cells with only a minor population of CD4 T cells,
depletion of CD4 but not CD8 cells prevented acute graft loss during mixed AMR. CD4
depletion eliminated antidonor alloantibodies and conferred protection from destruction of …