[HTML][HTML] Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation
M Xin, X Deng - Journal of Biological Chemistry, 2006 - ASBMB
Bax is a major proapoptotic member of the Bcl2 family that is required for apoptotic cell
death. We have recently discovered that Bax phosphorylation at serine 184 induced by
nicotine through activation of protein kinase AKT abolishes its proapoptotic function in
human lung cancer cells. Here we found that either treatment of cells with the protein
phosphatase 2A (PP2A) inhibitor okadaic acid or specific disruption of PP2A activity by
expression of SV40 small tumor antigen enhanced Bax phosphorylation, whereas C 2 …
death. We have recently discovered that Bax phosphorylation at serine 184 induced by
nicotine through activation of protein kinase AKT abolishes its proapoptotic function in
human lung cancer cells. Here we found that either treatment of cells with the protein
phosphatase 2A (PP2A) inhibitor okadaic acid or specific disruption of PP2A activity by
expression of SV40 small tumor antigen enhanced Bax phosphorylation, whereas C 2 …