[PDF][PDF] Rapamycin resistance: mTORC1 substrates hold some of the answers
The mechanism of action of the mTOR inhibitor rapamycin is poorly understood and why
certain mTORC1 phosphorylation sites are rapamycin insensitive remains elusive. Site-
specific analysis of mTORC1 substrates now suggests that the sequence composition of a
phosphorylation site determines whether it is sensitive to rapamycin and starvation.
certain mTORC1 phosphorylation sites are rapamycin insensitive remains elusive. Site-
specific analysis of mTORC1 substrates now suggests that the sequence composition of a
phosphorylation site determines whether it is sensitive to rapamycin and starvation.
Summary
The mechanism of action of the mTOR inhibitor rapamycin is poorly understood and why certain mTORC1 phosphorylation sites are rapamycin insensitive remains elusive. Site-specific analysis of mTORC1 substrates now suggests that the sequence composition of a phosphorylation site determines whether it is sensitive to rapamycin and starvation.
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