[HTML][HTML] A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation
MB Meyer, NA Benkusky, M Kaufmann, SM Lee… - Journal of Biological …, 2017 - ASBMB
The vitamin D endocrine system regulates mineral homeostasis through its activities in the
intestine, kidney, and bone. Terminal activation of vitamin D 3 to its hormonal form, 1α, 25-
dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), occurs in the kidney via the cytochrome P450
enzyme CYP27B1. Despite its importance in vitamin D metabolism, the molecular
mechanisms underlying the regulation of the gene for this enzyme, Cyp27b1, are unknown.
Here, we identified a kidney-specific control module governed by a renal cell-specific …
intestine, kidney, and bone. Terminal activation of vitamin D 3 to its hormonal form, 1α, 25-
dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), occurs in the kidney via the cytochrome P450
enzyme CYP27B1. Despite its importance in vitamin D metabolism, the molecular
mechanisms underlying the regulation of the gene for this enzyme, Cyp27b1, are unknown.
Here, we identified a kidney-specific control module governed by a renal cell-specific …