Osteocyte cellular senescence
Current osteoporosis reports, 2020•Springer
Abstract Purpose of Review Senescent cells are now known to accumulate in multiple
tissues with aging and through their inflammation (the senescence-associated secretory
phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of
senescent osteocytes in the context of bone loss. Recent Findings Numerous studies have
established that senescent osteocytes accumulate in the bone microenvironment with aging
in mice and in humans. Moreover, at least in mice, elimination of senescent cells results in …
tissues with aging and through their inflammation (the senescence-associated secretory
phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of
senescent osteocytes in the context of bone loss. Recent Findings Numerous studies have
established that senescent osteocytes accumulate in the bone microenvironment with aging
in mice and in humans. Moreover, at least in mice, elimination of senescent cells results in …
Purpose of Review
Senescent cells are now known to accumulate in multiple tissues with aging and through their inflammation (the senescence-associated secretory phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of senescent osteocytes in the context of bone loss.
Recent Findings
Numerous studies have established that senescent osteocytes accumulate in the bone microenvironment with aging in mice and in humans. Moreover, at least in mice, elimination of senescent cells results in attenuation of age-related bone loss. Osteocyte senescence also occurs in response to other cellular stressors, including radiotherapy, chemotherapy, and metabolic dysfunction, where it appears to mediate skeletal deterioration.
Summary
Osteocyte senescence is linked to bone loss associated with aging and other conditions. Senescent osteocytes are potential therapeutic targets to alleviate skeletal dysfunction. Additional studies better defining the underlying mechanisms as well as translating these exciting findings from mouse models to humans are needed.
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