[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors
JA Ballesteros, H Weinstein - Methods in neurosciences, 1995 - Elsevier
Publisher Summary This chapter discusses the integrated methods for the construction of
three-dimensional models and computational probing of structure–function relations in G
protein-coupled receptors (GPCR). The rapid pace of cloning and expression of G protein-
coupled receptors offers attractive opportunities to probe the structural basis of signal
transduction mechanisms at the level of these cell-surface receptors. Major insights have
emerged from comparisons and classifications of the amino acid sequences of GPCRs into …
three-dimensional models and computational probing of structure–function relations in G
protein-coupled receptors (GPCR). The rapid pace of cloning and expression of G protein-
coupled receptors offers attractive opportunities to probe the structural basis of signal
transduction mechanisms at the level of these cell-surface receptors. Major insights have
emerged from comparisons and classifications of the amino acid sequences of GPCRs into …