The glutamine debate in surgery and critical care
PE Wischmeyer - Current opinion in critical care, 2019 - journals.lww.com
Current opinion in critical care, 2019•journals.lww.com
Three recent meta-analyses have confirmed traditional GLN-supplemented (or 'GLN-
Complemented'–providing GLN for completeness of amino acid content) TPN is safe,
reduces mortality and improves outcome in surgical and ICU patients. Patients in need of
TPN, burns, trauma or malignancies should continue to benefit from supplemental GLN,
administered either intravenously at less than 0.35 g/kg/day or enterally at less than 0.5
g/kg/day. Further, a large trial of EN GLN supplementation in burns is ongoing. Thus, when …
Complemented'–providing GLN for completeness of amino acid content) TPN is safe,
reduces mortality and improves outcome in surgical and ICU patients. Patients in need of
TPN, burns, trauma or malignancies should continue to benefit from supplemental GLN,
administered either intravenously at less than 0.35 g/kg/day or enterally at less than 0.5
g/kg/day. Further, a large trial of EN GLN supplementation in burns is ongoing. Thus, when …
Summary
Three recent meta-analyses have confirmed traditional GLN-supplemented (or ‘GLN-Complemented’–providing GLN for completeness of amino acid content) TPN is safe, reduces mortality and improves outcome in surgical and ICU patients. Patients in need of TPN, burns, trauma or malignancies should continue to benefit from supplemental GLN, administered either intravenously at less than 0.35 g/kg/day or enterally at less than 0.5 g/kg/day. Further, a large trial of EN GLN supplementation in burns is ongoing. Thus, when used per guideline recommendations, the GLN story is likely still relevant to ICU outcomes and research.
Lippincott Williams & Wilkins