[HTML][HTML] Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells
H Wallin, J Apelqvist, F Andersson, U Ekström… - Journal of Biological …, 2017 - ASBMB
The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine
protease inhibitor cystatin C is internalized by some cancer cells, which affects cellular
properties. Here we aimed to investigate if uptake of cystatin C and the related inhibitor
cystatin E/M occur in melanoma cell lines and to evaluate to what extent the uptake affects
the legumain activity that is typically increased in melanoma. First we studied the basic
expression, secretion, and intracellular content of all type 2 cystatins as well as expression …
protease inhibitor cystatin C is internalized by some cancer cells, which affects cellular
properties. Here we aimed to investigate if uptake of cystatin C and the related inhibitor
cystatin E/M occur in melanoma cell lines and to evaluate to what extent the uptake affects
the legumain activity that is typically increased in melanoma. First we studied the basic
expression, secretion, and intracellular content of all type 2 cystatins as well as expression …