Oxidative damage and aging: spotlight on mitochondria
NJ Linford, SE Schriner, PS Rabinovitch - Cancer research, 2006 - AACR
NJ Linford, SE Schriner, PS Rabinovitch
Cancer research, 2006•AACRWhereas free radical damage has been proposed as a key component in the tissue
degeneration associated with aging, there has been little evidence that free radical damage
limits life span in mammals. The current research shows that overexpression of the
antioxidant enzyme catalase in mitochondria can extend mouse life span. These results
highlight the importance of mitochondrial damage in aging and suggest that when targeted
appropriately, boosting antioxidant defenses can increase mammalian life span.(Cancer …
degeneration associated with aging, there has been little evidence that free radical damage
limits life span in mammals. The current research shows that overexpression of the
antioxidant enzyme catalase in mitochondria can extend mouse life span. These results
highlight the importance of mitochondrial damage in aging and suggest that when targeted
appropriately, boosting antioxidant defenses can increase mammalian life span.(Cancer …
Abstract
Whereas free radical damage has been proposed as a key component in the tissue degeneration associated with aging, there has been little evidence that free radical damage limits life span in mammals. The current research shows that overexpression of the antioxidant enzyme catalase in mitochondria can extend mouse life span. These results highlight the importance of mitochondrial damage in aging and suggest that when targeted appropriately, boosting antioxidant defenses can increase mammalian life span. (Cancer Res 2006; 66(5): 2497-9)
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