Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver [S]
C Moffat, L Bhatia, T Nguyen, P Lynch, M Wang… - Journal of lipid …, 2014 - ASBMB
Acyl-CoA thioesterase (Acot) 2 localizes to the mitochondrial matrix and hydrolyses long-
chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxidative tissues
and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is
unknown. Using a model of adenoviral Acot2 overexpression in mouse liver (Ad-Acot2), we
show that Acot2 increases the utilization of FA substrate during the daytime in ad libitum-fed
mice, but the nighttime switch to carbohydrate oxidation is similar to control mice. In further …
chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxidative tissues
and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is
unknown. Using a model of adenoviral Acot2 overexpression in mouse liver (Ad-Acot2), we
show that Acot2 increases the utilization of FA substrate during the daytime in ad libitum-fed
mice, but the nighttime switch to carbohydrate oxidation is similar to control mice. In further …
