[HTML][HTML] Transient lymphopenia breaks costimulatory blockade-based peripheral tolerance and initiates cardiac allograft rejection
S Iida, T Suzuki, K Tanabe, A Valujskikh… - American Journal of …, 2013 - Elsevier
Lymphopenia is induced by lymphoablative therapies and chronic viral infections. We
assessed the impact of lymphopenia on cardiac allograft survival in recipients conditioned
with peritransplant costimulatory blockade (CB) to promote long-term graft acceptance. After
vascularized MHC-mismatched heterotopic heart grafts were stably accepted through CB,
lymphopenia was induced on day 60 posttransplant by 6.5 Gy irradiation or by
administration of anti-CD4 plus anti-CD8 mAb. Long-term surviving allografts were gradually …
assessed the impact of lymphopenia on cardiac allograft survival in recipients conditioned
with peritransplant costimulatory blockade (CB) to promote long-term graft acceptance. After
vascularized MHC-mismatched heterotopic heart grafts were stably accepted through CB,
lymphopenia was induced on day 60 posttransplant by 6.5 Gy irradiation or by
administration of anti-CD4 plus anti-CD8 mAb. Long-term surviving allografts were gradually …
