Identification of a radiation sensitivity gene expression profile in primary fibroblasts derived from patients who developed radiotherapy-induced fibrosis
HB Forrester, J Li, T Leong, MJ McKay… - Radiotherapy and …, 2014 - Elsevier
Background and purpose During radiotherapy, normal tissue is unavoidably exposed to
radiation which results in severe normal tissue reactions in a small fraction of patients.
Because those who are sensitive cannot be determined prior to radiotherapy, the doses are
limited to all patients to avoid an unacceptable number of severe adverse normal tissue
responses. This limitation restricts the optimal treatment for individuals who are more
tolerant to radiation. Genetic variation is a likely source for the normal tissue radiosensitivity …
radiation which results in severe normal tissue reactions in a small fraction of patients.
Because those who are sensitive cannot be determined prior to radiotherapy, the doses are
limited to all patients to avoid an unacceptable number of severe adverse normal tissue
responses. This limitation restricts the optimal treatment for individuals who are more
tolerant to radiation. Genetic variation is a likely source for the normal tissue radiosensitivity …