A murine model of IgE-mediated cow's milk hypersensitivity
X Li, BH Schofield, CK Huang, GI Kleiner… - Journal of Allergy and …, 1999 - Elsevier
Background: Cow's milk allergy (CMA) is one of the leading causes of food allergy in
children. Understanding the mechanisms involved in the development of CMA has been
hampered by the lack of suitable animal models. Objective: We sought to develop a mouse
model of IgE-mediated cow's milk hypersensitivity (CMH) that mimics the clinical features of
immediate CMA in humans. Methods: Three-week-old C3H/HeJ mice were sensitized by
intragastric administration of cow's milk (CM) plus cholera toxin and boosted 5 times at …
children. Understanding the mechanisms involved in the development of CMA has been
hampered by the lack of suitable animal models. Objective: We sought to develop a mouse
model of IgE-mediated cow's milk hypersensitivity (CMH) that mimics the clinical features of
immediate CMA in humans. Methods: Three-week-old C3H/HeJ mice were sensitized by
intragastric administration of cow's milk (CM) plus cholera toxin and boosted 5 times at …