Mast cells are critical effector cells in the pathophysiology of allergic asthma and other IgE-
mediated diseases. The Tec family of tyrosine kinases Itk and Btk serve as critical signal
amplifiers downstream of antigen receptors. Although both kinases are expressed and
activated in mast cells following FcϵRI stimulation, their individual contributions are not
clear. To determine whether these kinases play unique and/or complementary roles in
FcϵRI signaling and mast cell function, we generated Itk and Btk double knock-out mice …