Characterizing the topography of membrane receptors and signaling molecules from spatial patterns obtained using nanometer-scale electron-dense probes and …
J Zhang, K Leiderman, JR Pfeiffer, BS Wilson… - Micron, 2006 - Elsevier
The flow of information through a cell requires the constant remodeling of cell signaling
networks. Thus, spatially and temporally resolved microscopy of signaling components is
needed to understand the behavior of normal cells as well as to uncover abnormal behavior
leading to human disease. Nanoprobe labeling and transmission electron microscopy of
cytoplasmic face-up sheets of cell membrane have been developed as a high-resolution
approach to map the interactions of proteins and lipid during cell signaling. Membrane …
networks. Thus, spatially and temporally resolved microscopy of signaling components is
needed to understand the behavior of normal cells as well as to uncover abnormal behavior
leading to human disease. Nanoprobe labeling and transmission electron microscopy of
cytoplasmic face-up sheets of cell membrane have been developed as a high-resolution
approach to map the interactions of proteins and lipid during cell signaling. Membrane …