Different γ/δ T clones sustain GVM and GVH effects in multiple myeloma patients after non-myeloablative transplantation
S Galimberti, E Benedetti, F Morabito, I Petrini… - Leukemia research, 2006 - Elsevier
TCR γ/δ profiles were analyzed in 13 multiple myeloma patients after allogeneic non-
myeloablative transplantation. Results show that both aGVHD and minimal residual disease
(MRD) eradication did significantly affect TCR γ/δ profile. During follow-up, six patients
developed an aGVHD episode; in five of them, this event fitted with a modification of the TCR
profile. Eleven patients achieved PCR-negativity during follow-up. In the 90% of them, the
appearance of a new predominant TCR peak was concomitant to the disappearance of the …
myeloablative transplantation. Results show that both aGVHD and minimal residual disease
(MRD) eradication did significantly affect TCR γ/δ profile. During follow-up, six patients
developed an aGVHD episode; in five of them, this event fitted with a modification of the TCR
profile. Eleven patients achieved PCR-negativity during follow-up. In the 90% of them, the
appearance of a new predominant TCR peak was concomitant to the disappearance of the …