We have shown previously that Clock, microsomal triglyceride transfer protein (MTP), and
nocturnin are involved in the circadian regulation of intestinal lipid absorption. Here, we
clarified the role of apolipoprotein AIV (apoAIV) in the diurnal regulation of plasma lipids and
intestinal lipid absorption in mice. Plasma triglyceride in apoAIV−/− mice showed diurnal
variations similar to apoAIV+/+ mice; however, the increases in plasma triglyceride at night
were significantly lower in these mice. ApoAIV−/− mice absorbed fewer lipids at night and …