Effect of dehydroepiandrosterone (DHEA) on diabetes mellitus and obesity

K Aoki, Y Terauchi - Vitamins and hormones, 2018 - Elsevier
Type 2 diabetes is a metabolic disorder that is characterized by an impaired capacity to
secrete insulin, insulin resistance, or both. Dehydroepiandrosterone (DHEA), a steroid
hormone produced by the adrenal cortex, has been reported to have beneficial effects on
diabetes mellitus and obesity in animal models. DHEA and DHEA-sulfate (DHEA-S) have
been reported to increase not only insulin secretion of the pancreas but also insulin
sensitivity of the liver, adipose tissue, and muscle. We investigated the effects of DHEA on …