Background & Aims Estrogen participates in the control of energy homeostasis and lipid
metabolism. However the role of hepatic estrogen receptor α (ERα) in triglyceride (TG)
homeostasis remains poorly understood. This study aims to investigate the roles of estrogen
and ERα in the regulation of hepatic TG metabolism. Methods Liver TG metabolism was
analyzed in female mice with ovariectomy or tamoxifen treatment, and in hepatic ERα
knockdown or overexpression. Phenotypes and expression of genes were compared in …