Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer
WG BLACKARD, PS GUZELIAN, ME SMALL - Endocrinology, 1978 - academic.oup.com
WG BLACKARD, PS GUZELIAN, ME SMALL
Endocrinology, 1978•academic.oup.comDown regulation of insulin receptor number by insulin at physiological concentrations (10-9
M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in
monolayer. However, because insulin is rapidly degraded in this culture system, special
efforts are necessary to maintain the concentration of insulin in the medium in order to evoke
the down regulation phenomenon.
M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in
monolayer. However, because insulin is rapidly degraded in this culture system, special
efforts are necessary to maintain the concentration of insulin in the medium in order to evoke
the down regulation phenomenon.
Down regulation of insulin receptor number by insulin at physiological concentrations (10-9 M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration of insulin in the medium in order to evoke the down regulation phenomenon.
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