Randomized, double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock
S Warrillow, M Egi, R Bellomo - Critical care medicine, 2006 - journals.lww.com
Background: Marked potassium efflux prevents calcium entry into vascular smooth muscle
cells and may be responsible for the “vasoplegia” of septic shock. Blockade of adenosine
triphosphate (ATP)–sensitive potassium channels restores vascular tone in animal studies of
septic shock. The effect of such potassium channel blockade has not been previously
studied in humans. Objective: To test whether the administration of an ATP-sensitive
potassium (K ATP) channel blocker restores norepinephrine responsiveness in patients with …
cells and may be responsible for the “vasoplegia” of septic shock. Blockade of adenosine
triphosphate (ATP)–sensitive potassium channels restores vascular tone in animal studies of
septic shock. The effect of such potassium channel blockade has not been previously
studied in humans. Objective: To test whether the administration of an ATP-sensitive
potassium (K ATP) channel blocker restores norepinephrine responsiveness in patients with …
