Interferon-γ and interleukin-10 reciprocally regulate endothelial junction integrity and barrier function
Inflammatory bowel disease (IBD) is associated with Th1/Th2 cytokine dysregulation,
leukocyte extravasation, and tissue edema, but the mechanisms for cytokine-mediated
vascular dysfunction are not understood. To investigate how cytokines might control edema
in IBD, we determined vascular permeability and IFN-γ expression in two models of murine
colitis: SCID mice reconstituted with CD45RBhigh T-lymphocytes (CD45RBhigh/SCID mice),
and interleukin-10 gene deficient (IL-10−/−) mice. We also investigated the in vitro effects of …
leukocyte extravasation, and tissue edema, but the mechanisms for cytokine-mediated
vascular dysfunction are not understood. To investigate how cytokines might control edema
in IBD, we determined vascular permeability and IFN-γ expression in two models of murine
colitis: SCID mice reconstituted with CD45RBhigh T-lymphocytes (CD45RBhigh/SCID mice),
and interleukin-10 gene deficient (IL-10−/−) mice. We also investigated the in vitro effects of …