The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin
AV Birk, S Liu, YI Soong, W Mills, P Singh… - Journal of the …, 2013 - journals.lww.com
Ischemia causes AKI as a result of ATP depletion, and rapid recovery of ATP on reperfusion
is important to minimize tissue damage. ATP recovery is often delayed, however, because
ischemia destroys the mitochondrial cristae membranes required for mitochondrial ATP
synthesis. The mitochondria-targeted compound SS-31 accelerates ATP recovery after
ischemia and reduces AKI, but its mechanism of action remains unclear. Here, we used a
polarity-sensitive fluorescent analog of SS-31 to demonstrate that SS-31 binds with high …
is important to minimize tissue damage. ATP recovery is often delayed, however, because
ischemia destroys the mitochondrial cristae membranes required for mitochondrial ATP
synthesis. The mitochondria-targeted compound SS-31 accelerates ATP recovery after
ischemia and reduces AKI, but its mechanism of action remains unclear. Here, we used a
polarity-sensitive fluorescent analog of SS-31 to demonstrate that SS-31 binds with high …
