[HTML][HTML] Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis
X Dai, P She, F Chi, Y Feng, H Liu, D Jin, Y Zhao… - Journal of Biological …, 2013 - ASBMB
The Hippo tumor suppressor pathway plays important roles in organ size control through
Lats1/2 mediated phosphorylation of the YAP/TAZ transcription co-activators. However,
YAP/TAZ independent functions of the Hippo pathway are largely unknown. Here we report
a novel role of the Hippo pathway in angiogenesis. Angiomotin p130 isoform (AMOTp130) is
phosphorylated on a conserved HXRXXS motif by Lats1/2 downstream of GPCR signaling.
Phosphorylation disrupts AMOT interaction with F-actin and correlates with reduced F-actin …
Lats1/2 mediated phosphorylation of the YAP/TAZ transcription co-activators. However,
YAP/TAZ independent functions of the Hippo pathway are largely unknown. Here we report
a novel role of the Hippo pathway in angiogenesis. Angiomotin p130 isoform (AMOTp130) is
phosphorylated on a conserved HXRXXS motif by Lats1/2 downstream of GPCR signaling.
Phosphorylation disrupts AMOT interaction with F-actin and correlates with reduced F-actin …