[HTML][HTML] ULK1· ATG13· FIP200 complex mediates mTOR signaling and is essential for autophagy

IG Ganley, DH Lam, J Wang, X Ding, S Chen… - Journal of Biological …, 2009 - ASBMB
Autophagy is a degradative process that recycles long-lived and faulty cellular components.
It is linked to many diseases and is required for normal development. ULK1, a mammalian
serine/threonine protein kinase, plays a key role in the initial stages of autophagy, though
the exact molecular mechanism is unknown. Here we report identification of a novel protein
complex containing ULK1 and two additional protein factors, FIP200 and ATG13, all of which
are essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for …