[HTML][HTML] Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae
AN Patananan, J Capri, JP Whitelegge… - Journal of Biological …, 2014 - ASBMB
The spontaneous degradation of asparaginyl and aspartyl residues to isoaspartyl residues
is a common type of protein damage in aging organisms. Although the protein-l-isoaspartyl
(d-aspartyl) O-methyltransferase (EC 2.1. 1.77) can initiate the repair of l-isoaspartyl
residues to l-aspartyl residues in most organisms, no gene homolog or enzymatic activity is
present in the budding yeast Saccharomyces cerevisiae. Therefore, we used biochemical
approaches to elucidate how proteins containing isoaspartyl residues are metabolized in …
is a common type of protein damage in aging organisms. Although the protein-l-isoaspartyl
(d-aspartyl) O-methyltransferase (EC 2.1. 1.77) can initiate the repair of l-isoaspartyl
residues to l-aspartyl residues in most organisms, no gene homolog or enzymatic activity is
present in the budding yeast Saccharomyces cerevisiae. Therefore, we used biochemical
approaches to elucidate how proteins containing isoaspartyl residues are metabolized in …