Complement in the pathophysiology of human disease
MM Frank - New England Journal of Medicine, 1987 - Mass Medical Soc
MM Frank
New England Journal of Medicine, 1987•Mass Medical SocALMOST exactly 100 years ago it was noted that certain types of bacteria sensitized with
specific antibody would lyse in fresh normal serum. 1 That observation led to the discovery
of the proteins that constitute the complement system. It is now clear that those proteins not
only act to lyse target cells, but also have a broad role in the development of the
inflammatory response. Complement activity results from the sequential interaction of a large
number of plasma and cell-membrane interactive proteins—the complement system …
specific antibody would lyse in fresh normal serum. 1 That observation led to the discovery
of the proteins that constitute the complement system. It is now clear that those proteins not
only act to lyse target cells, but also have a broad role in the development of the
inflammatory response. Complement activity results from the sequential interaction of a large
number of plasma and cell-membrane interactive proteins—the complement system …
ALMOST exactly 100 years ago it was noted that certain types of bacteria sensitized with specific antibody would lyse in fresh normal serum.1 That observation led to the discovery of the proteins that constitute the complement system. It is now clear that those proteins not only act to lyse target cells, but also have a broad role in the development of the inflammatory response.
Complement activity results from the sequential interaction of a large number of plasma and cell-membrane interactive proteins — the complement system — whose number is now thought to approach 25. There is now a considerable body . . .
The New England Journal Of Medicine