Prader–Willi Syndrome (PWS) is a neurodevelopmental genetic disorder caused by loss of
expression of imprinted, paternally inherited genes on chromosome 15q11q13. This
imprinted gene cluster has its homologous region on mouse chromosome 7C. The
extremely well conserved synteny between the human and the murine regions gave origin to
the generation of mouse models for PWS, which facilitated investigations of the role and
function of single genes or gene clusters in the pathogenesis of this disease. In this review …