Legionella pneumophila is an intracellular bacterium that causes an acute form of
pneumonia called Legionnaires' disease. After infection of human macrophages, the
Legionella-containing phagosome (LCP) avoids fusion with the lysosome allowing
intracellular replication of the bacterium. In macrophages derived from most mouse strains,
the LCP is delivered to the lysosome resulting in Legionella degradation and restricted
bacterial growth. Mouse macrophages lacking the NLR protein Ipaf or its downstream …