Role of ABC transporters in lipid transport and human disease
EJ Tarling, TQ de Aguiar Vallim, PA Edwards - Trends in Endocrinology & …, 2013 - cell.com
EJ Tarling, TQ de Aguiar Vallim, PA Edwards
Trends in Endocrinology & Metabolism, 2013•cell.comAlmost half of the 48 human ATP-binding cassette (ABC) transporter proteins are thought to
facilitate the ATP-dependent translocation of lipids or lipid-related compounds. Such
substrates include cholesterol, plant sterols, bile acids, phospholipids, and sphingolipids.
Mutations in a substantial number of the 48 human ABC transporters have been linked to
human disease. Indeed the finding that 12 diseases have been associated with abnormal
lipid transport and/or homeostasis demonstrates the importance of this family of transporters …
facilitate the ATP-dependent translocation of lipids or lipid-related compounds. Such
substrates include cholesterol, plant sterols, bile acids, phospholipids, and sphingolipids.
Mutations in a substantial number of the 48 human ABC transporters have been linked to
human disease. Indeed the finding that 12 diseases have been associated with abnormal
lipid transport and/or homeostasis demonstrates the importance of this family of transporters …
Almost half of the 48 human ATP-binding cassette (ABC) transporter proteins are thought to facilitate the ATP-dependent translocation of lipids or lipid-related compounds. Such substrates include cholesterol, plant sterols, bile acids, phospholipids, and sphingolipids. Mutations in a substantial number of the 48 human ABC transporters have been linked to human disease. Indeed the finding that 12 diseases have been associated with abnormal lipid transport and/or homeostasis demonstrates the importance of this family of transporters in cell physiology. This review highlights the role of ABC transporters in lipid transport and movement, in addition to discussing their roles in cellular homeostasis and inherited disorders.
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