Neutrophil energetics and oxygen sensing

SR Walmsley, MKB Whyte - … Journal of the American Society of …, 2014 - ashpublications.org
SR Walmsley, MKB Whyte
Blood, The Journal of the American Society of Hematology, 2014ashpublications.org
In this issue of Blood, Jun et al, through the study of neutrophils deficient in the glucose-6-
phosphate transporter, describe a novel role for the peroxisome proliferator-activated
receptor-g (PPARG) pathway in the regulation of key neutrophil functions and link this to
concomitant hypoxia-inducible factor (HIF) 1a stabilization. 1
In this issue of Blood, Jun et al, through the study of neutrophils deficient in the glucose-6-phosphate transporter, describe a novel role for the peroxisome proliferator-activated receptor-g (PPARG) pathway in the regulation of key neutrophil functions and link this to concomitant hypoxia-inducible factor (HIF) 1a stabilization. 1
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