[HTML][HTML] Predicted expansion of the claudin multigene family

K Mineta, Y Yamamoto, Y Yamazaki, H Tanaka, Y Tada… - FEBS letters, 2011 - Elsevier
K Mineta, Y Yamamoto, Y Yamazaki, H Tanaka, Y Tada, K Saito, A Tamura, M Igarashi…
FEBS letters, 2011Elsevier
Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the
paracellular permselective barrier. They are produced by a multi-gene family of 24 reported
members in mouse and human. Based on a comprehensive search combined with
phylogenetic analyses, we identified three novel claudins (claudin-25,-26, and-27).
Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue-
and/or developmental stage-dependent manner. Claudins-25 and-26, but not claudin-27 …
Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but not claudin-27, were immunofluorescently localized to TJs when exogenously expressed in cultured MDCK and Eph epithelial cell lines. These findings expand the claudin family to include at least 27 members. STRUCTURED SUMMARY: Claudin-25 and ZO-1colocalize by fluorescence microscopy(View interaction) ZO-1 and Claudin-26colocalize by fluorescence microscopy(View interaction)
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