Estrogen Is Renoprotective via  a Nonreceptor-dependent Mechanism after Cardiac Arrest In Vivo

MP Hutchens, T Nakano, Y Kosaka… - The Journal of the …, 2010 - pubs.asahq.org
Background Severe ischemia induces renal injury less frequently in women than men. In this
study, cardiac arrest and cardiopulmonary resuscitation were used to assess whether
estradiol is renoprotective via an estrogen receptor (ER)-dependent mechanism. Materials
and Methods Male and female C57BL/6 and ER gene-deleted mice underwent 10 min of
cardiac arrest followed by cardiopulmonary resuscitation. Serum chemistries and renal
stereology were measured 24 h after arrest. Results Estrogen did not affect mean arterial …