Messengers without borders: mediators of systemic inflammatory response in AKI

BB Ratliff, MM Rabadi, R Vasko, K Yasuda… - Journal of the …, 2013 - journals.lww.com
The list of signals sent by an injured organ to systemic circulation, so-called danger signals,
is growing to include multiple metabolites and secreted moieties, thus revealing a highly
complex and integrated network of interlinked systemic proinflammatory and
proregenerative messages. Emerging new data indicate that, apart from the well established
local inflammatory response to AKI, danger signaling unleashes a cascade of precisely
timed, interdependent, and intensity-gradated mediators responsible for development of the …