Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines

LC Racusen, C Monteil, A Sgrignoli, M Lucskay… - Journal of Laboratory …, 1997 - Elsevier
Few model systems exist for the study of injury to human renal proximal tubule epithelium.
Optimized differentiated human renal epithelial cell lines with extended in vitro growth
potential would provide an alternative model system to primary culture or other available
non-human mammalian kidney cell lines. For this purpose, human renal tubule epithelial
cells were isolated from normal kidney cortex and exposed in culture to a hybrid
immortalizing virus, adenovirus 12-SV40. Cell lines were developed by limiting dilution, and …