Airway hyperresponsiveness in children with sickle cell anemia
JJ Field, J Stocks, FJ Kirkham, CL Rosen, DJ Dietzen… - Chest, 2011 - Elsevier
Background The high prevalence of airway hyperresponsiveness (AHR) among children
with sickle cell anemia (SCA) remains unexplained. Methods To determine the relationship
between AHR, features of asthma, and clinical characteristics of SCA, we conducted a
multicenter, prospective cohort study of children with SCA. Dose response slope (DRS) was
calculated to describe methacholine responsiveness, because 30% of participants did not
achieve a 20% decrease in FEV 1 after inhalation of the highest methacholine …
with sickle cell anemia (SCA) remains unexplained. Methods To determine the relationship
between AHR, features of asthma, and clinical characteristics of SCA, we conducted a
multicenter, prospective cohort study of children with SCA. Dose response slope (DRS) was
calculated to describe methacholine responsiveness, because 30% of participants did not
achieve a 20% decrease in FEV 1 after inhalation of the highest methacholine …