[HTML][HTML] Skeletal muscle Foxo1 (Fkhr) transgenic mice have less skeletal muscle mass, down-regulated type I (Slow twitch/red muscle) fiber genes, and impaired …
Y Kamei, S Miura, M Suzuki, Y Kai, J Mizukami… - Journal of Biological …, 2004 - ASBMB
FOXO1, a member of the FOXO forkhead type transcription factors, is markedly up-regulated
in skeletal muscle in energy-deprived states such as fasting and severe diabetes, but its
functions in skeletal muscle have remained poorly understood. In this study, we created
transgenic mice specifically overexpressing FOXO1 in skeletal muscle. These mice weighed
less than the wild-type control mice, had a reduced skeletal muscle mass, and the muscle
was paler in color. Microarray analysis revealed that the expression of many genes related …
in skeletal muscle in energy-deprived states such as fasting and severe diabetes, but its
functions in skeletal muscle have remained poorly understood. In this study, we created
transgenic mice specifically overexpressing FOXO1 in skeletal muscle. These mice weighed
less than the wild-type control mice, had a reduced skeletal muscle mass, and the muscle
was paler in color. Microarray analysis revealed that the expression of many genes related …