IL-12 inhibits the TGF-β-dependent T cell developmental programs and skews the TGF-β-induced differentiation into a Th1-like direction
J Prochazkova, K Pokorna, V Holan - Immunobiology, 2012 - Elsevier
The development and differentiation of T helper (Th) cell subsets is a highly plastic process
which is strictly regulated by cytokines. Here we show that the transforming growth factor β
(TGF-β)-dependent differentiation programs are negatively regulated by interleukin-12 (IL-
12). The development of TGF-β-induced regulatory T cells (iTregs) or TGF-β/IL-6 activated
Th17 cells from purified mouse CD4+ CD25− T cells, stimulated with monoclonal antibody
anti-CD3, was abrogated in the presence of IL-12 and a different developmental program …
which is strictly regulated by cytokines. Here we show that the transforming growth factor β
(TGF-β)-dependent differentiation programs are negatively regulated by interleukin-12 (IL-
12). The development of TGF-β-induced regulatory T cells (iTregs) or TGF-β/IL-6 activated
Th17 cells from purified mouse CD4+ CD25− T cells, stimulated with monoclonal antibody
anti-CD3, was abrogated in the presence of IL-12 and a different developmental program …
