Chronic calcineurin inhibitor nephrotoxicity: reflections on an evolving paradigm
RS Gaston - Clinical Journal of the American Society of …, 2009 - journals.lww.com
Use of the calcineurin inhibitors (CNI) cyclosporine and tacrolimus has revolutionized solid
organ transplantation. For more than 30 yr, the transplant community has dealt with
nephrotoxicity attributed to these agents. Acute renal vasoconstriction (as described by
many investigators, including John Curtis and colleagues) is the unequivocal consequence
of their use; chronic CNI nephropathy, although indistinct in terms of histology and
pathophysiology, has become accepted as a major cause of late kidney allograft failure. This …
organ transplantation. For more than 30 yr, the transplant community has dealt with
nephrotoxicity attributed to these agents. Acute renal vasoconstriction (as described by
many investigators, including John Curtis and colleagues) is the unequivocal consequence
of their use; chronic CNI nephropathy, although indistinct in terms of histology and
pathophysiology, has become accepted as a major cause of late kidney allograft failure. This …