Enteroendocrine cell types revisited
MS Engelstoft, KL Egerod, ML Lund… - Current opinion in …, 2013 - Elsevier
Highlights•Transgenic reporter mice revolutionize enteroendocrine understanding.•Intestinal
enteroendocrine cells co-express six functionally related peptides.•Somatostatin and 5-HT
are pan-GI tract enteroendocrine cell types.•Gastric ghrelin cells differ significantly from
intestinal ghrelin–motilin cells.•Gastrin, pure-ghrelin and histamine (ECL) cells are gastro-
endocrine restricted.The GI-tract is profoundly involved in the control of metabolism through
peptide hormones secreted from enteroendocrine cells scattered throughout the gut …
enteroendocrine cells co-express six functionally related peptides.•Somatostatin and 5-HT
are pan-GI tract enteroendocrine cell types.•Gastric ghrelin cells differ significantly from
intestinal ghrelin–motilin cells.•Gastrin, pure-ghrelin and histamine (ECL) cells are gastro-
endocrine restricted.The GI-tract is profoundly involved in the control of metabolism through
peptide hormones secreted from enteroendocrine cells scattered throughout the gut …