[HTML][HTML] Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion
S Fatma, R Yakubov, K Anwar, MM Hussain - Journal of lipid research, 2006 - ASBMB
Pluronic L81 (PL81) inhibits fat absorption, and other Pluronic copolymers help overcome
drug resistance in cancer cells. To understand how PL81 acts, we synthesized a
radiolabeled analog,[14 C] PL81, and showed that it was structurally similar to PL81 based
on 1 H NMR as well as mass spectrometric analysis.[14 C] PL81 inhibited the secretion of
chylomicrons (CMs), lipoproteins essential for fat absorption, by differentiated Caco-2 cells
similar to PL81. Moreover, PL81 competed with the cellular uptake of [14 C] PL81. Thus,[14 …
drug resistance in cancer cells. To understand how PL81 acts, we synthesized a
radiolabeled analog,[14 C] PL81, and showed that it was structurally similar to PL81 based
on 1 H NMR as well as mass spectrometric analysis.[14 C] PL81 inhibited the secretion of
chylomicrons (CMs), lipoproteins essential for fat absorption, by differentiated Caco-2 cells
similar to PL81. Moreover, PL81 competed with the cellular uptake of [14 C] PL81. Thus,[14 …