Endocrine cells, enteric neurons and enterocytes provide an integrated functional defense
against luminal factors, including nutrients, microbes and toxins. Prominent among intrinsic
mediators is peptide YY (PYY) which is present in∼ 50% of colorectal endocrine cells and
neuropeptide Y (NPY), a neurotransmitter expressed in submucous and myenteric nerves.
Both peptides and their long fragments (PYY (3–36) and NPY (3–36)) are potent, long-
lasting anti-secretory agents in vitro and in vivo and, they provide significant Y receptor …